Linked Life Data

6136173

Source:http://linkedlifedata.com/resource/pubmed/id/6136173

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-9-23
pubmed:abstractText
Diethylcarbamazine (DEC) induced dose dependent adherence of normal spleen cells from Mastomys natalensis to microfilariae of L. carinii in the presence of serum from Mastomys infected with L. carinii or normal serum. The effect could be also induced, using fresh, normal human serum and human blood leucocytes. The responsible serum factor was heat labile (56 degrees C, 30 min) and was eliminated from the sera by pretreatment with Inulin. The activity could be reconstituted by normal serum. Cell adhesion was inhibited by 0.004 MEDTA while 0.004 M EGTA had only a weak inhibitory effect. The addition of Mg++ led to high adherence rates in the presence of EGTA. The data indicate that DEC activates complement on the surface of the larval sheath by the alternate pathway. Adherent Mastomys cells or human cells had a cytotoxic effect on the larvae. The death of the microfilariae did not depend on the loss of the larval sheath.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0001-706X
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
129-38
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Diethylcarbamazine dependent, complement mediated, adherence and cytotoxicity of cells on microfilariae of Litomosoides carinii.
pubmed:publicationType
Journal Article, In Vitro