Linked Life Data

6135712

Source:http://linkedlifedata.com/resource/pubmed/id/6135712

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-9-20
pubmed:abstractText
We have shown recently that norepinephrine stimulates muscle cell hypertrophy in primary cultures from the neonatal rat ventricle and that this stimulation is not blocked by the beta adrenergic antagonist propranolol. The present study was done to define the adrenergic specificity of the myocyte hypertrophic response to norepinephrine. 90% pure, single-cell cultures of nongrowing myocytes were maintained in serum-free medium 199 with transferin and insulin. Myocyte size was quantitated 48 h after addition of adrenergic agents, by measuring cell volume, cell surface area, and cell protein. L-norepinephrine increased myocyte size to a maximum 150% of control; half-maximum effect was obtained at a concentration of 0.2 microM. This increase in cell size was inhibited by the nonselective alpha adrenergic antagonist phentolamine and by the alpha 1 adrenergic antagonists prazosin and terazosin; it was not inhibited by propranolol or by the alpha 2 adrenergic antagonist yohimbine. The beta adrenergic agonist isoproterenol did not increase cell size. Thus, norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-153085, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-197396, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-227385, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-23964, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-4148138, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-4235985, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-6123220, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-6126793, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-6127414, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-6216022, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-6266734, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-6267618, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-6282182, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-6284406, http://linkedlifedata.com/resource/pubmed/commentcorrection/6135712-7053872
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
732-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't