Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1983-8-11
|
| pubmed:abstractText |
Single oral administration of K-351 showed a long lasting antihypertensive action in spontaneously hypertensive rats, accompanied by slight bradycardia. K-351 reduced systolic and diastolic blood pressures almost to the same degree. K-351 showed a competitive antagonistic effect on norepinephrine-induced contraction of isolated canine blood vessels. This alpha-adrenoceptor blocking action of K-351 was about 5 times less potent than that of phentolamine. Furthermore, K-351 produced a nitroglycerin-like relaxant action on isolated blood vessels previously contracted with high K+. K-351 showed a nonselective beta-adrenoceptor blocking action in isolated guinea-pig atrium and trachea, and its action was about 2 times more potent than that of propranolol. K-351 did not show an intrinsic sympathomimetic action. In anesthethized dogs, low doses of K-351 reduced the heart rate and antagonized the positive chronotropic and hypotensive responses to isoproterenol. In higher doses, K-351 lowered the blood pressure and showed an antagonistic action on the pressor response to phenylephrine. The desnitro compound of K-351 was deprived of vasoactive properties on isolated blood vessels and hypotensive activity. Results have revealed that K-351 has both beta-adrenoceptor blocking and vasoactive properties which may result in an antihypertensive effect without reflex tachycardia in hypertensive animals.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/K 351,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Propanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0301-4533
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
262
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
132-49
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6135395-Adrenergic alpha-Antagonists,
pubmed-meshheading:6135395-Adrenergic beta-Antagonists,
pubmed-meshheading:6135395-Animals,
pubmed-meshheading:6135395-Antihypertensive Agents,
pubmed-meshheading:6135395-Blood Pressure,
pubmed-meshheading:6135395-Dogs,
pubmed-meshheading:6135395-Dose-Response Relationship, Drug,
pubmed-meshheading:6135395-Guinea Pigs,
pubmed-meshheading:6135395-Heart Rate,
pubmed-meshheading:6135395-Hypertension,
pubmed-meshheading:6135395-Myocardial Contraction,
pubmed-meshheading:6135395-Norepinephrine,
pubmed-meshheading:6135395-Potassium,
pubmed-meshheading:6135395-Propanolamines,
pubmed-meshheading:6135395-Rats,
pubmed-meshheading:6135395-Rats, Inbred Strains,
pubmed-meshheading:6135395-Vasoconstriction,
pubmed-meshheading:6135395-Vasodilator Agents
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
Vasoactive and beta-adrenoceptor blocking properties of 3,4-dihydro-8-(2-hydroxy-3-isopropylamino) propoxy-3-nitroxy-2H-1-benzopyran (K-351), a new antihypertensive agent.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|