Linked Life Data

6133951

Source:http://linkedlifedata.com/resource/pubmed/id/6133951

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1983-7-8
pubmed:abstractText
Agonist interaction with beta 1 and beta 2 adrenoceptors in rat and rabbit lung has been examined using ligand binding techniques and the results are discussed in relation to current models of beta-adrenoceptor-adenylate cyclase coupling. Agonist binding has been assessed by examining the ability of isoprenaline or salbutamol to displace the labelled antagonist 3H-dihydroalprenolol (3H-DHA) from specific receptor sites. Beta 1 and beta 2 adrenoceptors, even within the same tissue, exhibited different ion and temperature requirements for guanine nucleotide modulation of agonist binding. Thus, in contrast to the situation at beta 2 sites, agonist binding to beta 1 adrenoceptors was only sensitive to GTP if incubations were performed at physiological temperatures in the presence of Mg++ ions. These findings suggest that there may be different receptor-effector coupling relationships between the two beta-adrenoceptor subtypes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0197-5110
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Agonist binding to mammalian beta 1 and beta 2 adrenoceptors: modulation by guanine nucleotides and magnesium.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't