Linked Life Data

6133729

Source:http://linkedlifedata.com/resource/pubmed/id/6133729

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-7-8
pubmed:abstractText
14C-labeled mepindolol was rapidly and almost completely absorbed in the rat and dog after oral administration of 0.4 mg/kg, achieving maximum concentrations in the plasma after 1-2 hr. In the rhesus monkey, absorption was distinctly slower. Higher doses (25 mg/kg) given to rats and dogs exhibited maximum levels at 6 hr. The bioavailability of low doses was 1-2% in the rat and 40% in the dog. Plasma levels of unchanged drug declined biphasically in the dog with half-lives of 8 min and 3 hr. Excretion of radioactivity was mainly biliary in the rat. In the dog, elimination was equal in feces and urine, and in the rhesus monkey it was mainly renal. Although in the rat and rhesus monkey 14C-active compounds were completely eliminated, substantial amounts of metabolites were retained in the liver of the dog even 10 days after administration. After repeated administration, labeled substances accumulated in the dog, reaching maximum concentrations in the liver.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0090-9556
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Pharmacokinetics of mepindolol sulfate in the rat, dog, and rhesus monkey. Studies on species differences.
pubmed:publicationType
Journal Article, Comparative Study