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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1983-5-5
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pubmed:abstractText |
Experiments were performed to find biochemical evidence of an activation of endogenous opiate peptides in the brain by incentive reward. A method used to estimate specific in vivo opiate binding in rats using the labelled opiate agonist, 3H-etorphine, indicated a considerable reduction in opiate binding exclusively in the hypothalamus of non-deprived animals given a highly palatable food to eat for 20 min. Radioimmunoassay of the hypothalamus of rats under similar conditions found a pronounced drop in the concentration of beta-endorphin, but not in dynorphin, in the hypothalamus, indicating a release and breakdown of beta-endorphin. Therefore, the reduction in opiate binding in the hypothalamus may at least be partially explained by an occupation of opiate receptors by beta-endorphin, causing a reduced availability of receptors to etorphine. A possible role of hypothalamic beta-endorphin in the facilitation of reward pathways in the brain is discussed.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dynorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Endorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Etorphine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Endorphin
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0091-3057
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
18
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
443-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6132412-Animals,
pubmed-meshheading:6132412-Drinking,
pubmed-meshheading:6132412-Dynorphins,
pubmed-meshheading:6132412-Eating,
pubmed-meshheading:6132412-Endorphins,
pubmed-meshheading:6132412-Etorphine,
pubmed-meshheading:6132412-Hypothalamus,
pubmed-meshheading:6132412-Male,
pubmed-meshheading:6132412-Motivation,
pubmed-meshheading:6132412-Rats,
pubmed-meshheading:6132412-Rats, Inbred Strains,
pubmed-meshheading:6132412-Receptors, Opioid,
pubmed-meshheading:6132412-Reward,
pubmed-meshheading:6132412-Taste,
pubmed-meshheading:6132412-beta-Endorphin
|
pubmed:year |
1983
|
pubmed:articleTitle |
Activation of hypothalamic beta-endorphin pools by reward induced by highly palatable food.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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