Linked Life Data

6131420

Source:http://linkedlifedata.com/resource/pubmed/id/6131420

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1206
pubmed:dateCreated
1983-4-15
pubmed:abstractText
We describe a model for the mechanism by which Ca channel inactivation might depend on calcium entry. Ca is assumed to bind to a site at the internal membrane surface to cause inactivation of Ca channels. We assume that Ca that enters through the membrane accumulates in a submembrane compartment and also make simplifying assumptions about Ca buffering and removal. Our model predicts the results of single- and double-pulse voltage-clamp experiments well. The predicted turn-off of Ca current is non-exponential. The model also predicts that procedures that slow inactivation will increase peak Ca current and suggests that both two-phase turn-off of currents and failure of normalized current to recover to 1.0 in two-pulse experiments may be explained without assuming a voltage-dependent component of inactivation or two populations of Ca channels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0080-4649
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
217
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-10
pubmed:dateRevised
2007-4-30
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
A binding-site model for calcium channel inactivation that depends on calcium entry.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't