Linked Life Data

6130545

Source:http://linkedlifedata.com/resource/pubmed/id/6130545

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1097
pubmed:dateCreated
1983-3-11
pubmed:abstractText
Ion-selective microelectrodes have been used to compare the mechanisms controlling intracellular Cl- activity in skeletal and cardiac muscle. In frog Sartorius skeletal muscle fibres, Cl- levels are low (about 3 mM) and are determined mainly passively. The effect of any Cl- transport system will be quickly short-circuited through the high membrane Cl- conductance. In contrast, the sheep-heart Purkinje fibre, like other cardiac tissues, contains higher than passive levels of intracellular Cl- (20-30 mM). Many Cl- movements occur, not through Cl- channels (the permeability for Cl- is low), but by a Cl- -HCO3- countertransport system. High internal Cl- levels are achieved by an exchange of extracellular Cl- for intracellular HCO3-, which acidifies the fibre by 0.3 pH. Anion exchange in heart differs from that proposed for other excitable cells in that it is not specialized to compensate for an intracellular acidosis. Instead, it can prevent the fibres from becoming too alkaline by promoting a bicarbonate efflux and a chloride influx whenever internal bicarbonate levels rise. Possible reasons for this are briefly discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0962-8436
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
299
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
537-48
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Chloride activity and its control in skeletal and cardiac muscle.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't