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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
16-17
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pubmed:dateCreated |
1983-3-24
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pubmed:abstractText |
Dynorphin(1-8) immunoreactivity was visualized by immunohistofluorescence in hypothalamic magnocellular neurons of the rat. No immunoreactive met-enkephalin-Arg6-Gly7-Leu8, a fragment of the adrenal medulla pro-enkephalin molecule, was detected in magnocellular neurons. However, a strong met-enkephalin-Arg6-Gly7-Leu8-like immunostaining was seen in other regions of the brain. These results suggest that in magnocellular neurons dynorphin(1-8) exists independently from pro-enkephalin and therefore the magnocellular neurons represent a third opioid peptide neuronal system in brain. These observations, however, do not rule out a coexistence of proenkephalin and dynorphin-related peptides in other regions of the brain.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0024-3205
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1761-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6130434-Animals,
pubmed-meshheading:6130434-Dynorphins,
pubmed-meshheading:6130434-Endorphins,
pubmed-meshheading:6130434-Enkephalin, Methionine,
pubmed-meshheading:6130434-Fluorescent Antibody Technique,
pubmed-meshheading:6130434-Histocytochemistry,
pubmed-meshheading:6130434-Hypothalamus,
pubmed-meshheading:6130434-Neurons,
pubmed-meshheading:6130434-Rats
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pubmed:articleTitle |
Immunohistochemical localization of dynorphin (1-8) in hypothalamic magnocellular neurons: evidence for absence of proenkephalin.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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