Linked Life Data

6130187

Source:http://linkedlifedata.com/resource/pubmed/id/6130187

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-3-11
pubmed:abstractText
The development of an isolated stomach preparation from immature rats is described. Acid secretion was measured by titration of mucosal samples taken at 15 min intervals. Nonstimulated acid secretion was generally in the range 60-180 mumol H+g-1 wet weight of mucosa hr-1 and was maintained for up to 5.5 hr. A small proportion of stomachs (20%) had a higher level of spontaneous secretion which fell to the more usual low level within 1.5 hr. Pentagastrin (1.3 X 10(-8) M-1.3 X 10(-7) M), bethanechol (2 X 10(-6) M-3 X 10(-5) M), histamine (5 X 10(-6) M-5 X 10(-4) M) and theophylline (2 X 10(-4) M-1 X 10(-3) M) induced concentration-dependent stimulation of acid secretion. Linear log-dose response relationships were obtained for each of the four stimulants. The regression coefficients from each drug study, calculated over a similar increase in concentration, were not significantly different from one another. The maximal secretory rates recorded with the four secretagogues were comparable, range 152.5-226.0 mumol H+g-1hr-1. The methodology and results are compared with other mammalian in vitro stomach preparations currently used to study the physiology and pharmacology of gastric acid secretion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0160-5402
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-212
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The rat isolated stomach sheet; an in vitro model for the study of the physiology and pharmacology of gastric acid secretion.
pubmed:publicationType
Journal Article, In Vitro