Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6359
pubmed:dateCreated
1983-3-11
pubmed:abstractText
The hypnotic and residual sedative effects of the first and seventh of seven regular night-time doses of nitrazepam 5 mg, temazepam 20 mg, and placebo were studied in 58 elderly inpatients. Plasma temazepam and nitrazepam concentrations rose by about 50% and 113% respectively between the mornings of day 1 and day 7. Patients reported sleeping well more often after the first dose of either hypnotic (p less than 0.05), but there was no difference after the seventh dose. Reaction time was unchanged on the morning after the first dose but was significantly prolonged after the seventh dose of both hypnotics (p less than 0.01). The time taken to eliminate the letter E from a page of prose tended to be prolonged after the first dose of both drugs (temazepam v placebo, p less than 0.05; nitrazepam v placebo, not significant) and was further prolonged on the morning after the seventh dose of nitrazepam (nitrazepam v placebo, p less than 0.05). Thus plasma accumulation of the drug was associated with a deterioration in daytime performance. This change in performance did not correlate with age, cerebral blood flow, or plasma concentration, but patients of low intelligence tended to be more severely affected.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6129914-13961, http://linkedlifedata.com/resource/pubmed/commentcorrection/6129914-318894, http://linkedlifedata.com/resource/pubmed/commentcorrection/6129914-376048, http://linkedlifedata.com/resource/pubmed/commentcorrection/6129914-4412804, http://linkedlifedata.com/resource/pubmed/commentcorrection/6129914-456400, http://linkedlifedata.com/resource/pubmed/commentcorrection/6129914-6109555, http://linkedlifedata.com/resource/pubmed/commentcorrection/6129914-630787, http://linkedlifedata.com/resource/pubmed/commentcorrection/6129914-656280, http://linkedlifedata.com/resource/pubmed/commentcorrection/6129914-7083558, http://linkedlifedata.com/resource/pubmed/commentcorrection/6129914-7285482, http://linkedlifedata.com/resource/pubmed/commentcorrection/6129914-772173
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0267-0623
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
286
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
100-2
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Hypnotic accumulation and hangover in elderly inpatients: a controlled double-blind study of temazepam and nitrazepam.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't