Linked Life Data

6129636

Source:http://linkedlifedata.com/resource/pubmed/id/6129636

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1205
pubmed:dateCreated
1983-2-14
pubmed:abstractText
When synaptosomes are prepared from rat brain and incubated in Krebs solution, the presynaptic bulb develops a coil of microtubules (mts). Various considerations indicate that the coil does not have a cytoskeletal supportive function. Synaptosome coil mts show certain peculiarities, e.g. they thrive during incubation in Krebs solution (dendritic mts are depolymerized in Krebs solution) and they show no protofilament molecular substructure with tannic acid. Dendritic mts show clearly a 13 protofilament substructure when processed in the same way. Synaptosomal coil mts are sensitive to micromolar calcium and are depolymerized by treatment of the synaptosomes with veratridine or A23187. Our evidence indicates that coil mts of synaptosome and synaptic vesicle clothed mts of 'intact' albumin-treated synapses are different morphological and functional entities. As mentioned above, the function of coil mts remains enigmatic, while the mts seen in albumin-treated synapses could well have a role in synaptic vesicle translocation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0080-4649
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
216
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
385-96
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The enigma of microtubule coils in brain synaptosomes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.