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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1982-12-21
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pubmed:abstractText |
Colchicine-resistant Chinese hamster ovary (CHO) cell mutants whose resistance results from reduced drug permeability have been isolated previously in our laboratories. This reduced permeability affects a wide range of unrelated drugs, resulting in the mutants displaying a multiple drug resistance phenotype. A 170,000-dalton cell surface glycoprotein (P-glycoprotein) was identified, and its expression appears to correlate with the degree of resistance. In this study we were able to confer the multiple drug resistance phenotype on sensitive mouse L cells by DNA-mediated gene transfer of DNA obtained from the colchicine-resistant mutants. P-glycoprotein was detected in plasma membranes of these DNA transformants by staining with an antiserum raised against membranes of mutant CHO cells. These results are consistent with a causal relationship between P-glycoprotein expression and the multiple drug resistance phenotype.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-1028172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-1068629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-1203765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-13293190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-14056989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-208776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-388439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-4321087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-4326772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-4473229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-4547236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-4736505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-4855907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-500733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-5279808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-566474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-57118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-571759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-6929276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-6931407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-715457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-7448783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-875055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-94518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6127625-999943
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
881-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6127625-Animals,
pubmed-meshheading:6127625-Cells, Cultured,
pubmed-meshheading:6127625-Colchicine,
pubmed-meshheading:6127625-Cricetinae,
pubmed-meshheading:6127625-Cricetulus,
pubmed-meshheading:6127625-DNA,
pubmed-meshheading:6127625-Drug Resistance,
pubmed-meshheading:6127625-Gene Expression Regulation,
pubmed-meshheading:6127625-Glycoproteins,
pubmed-meshheading:6127625-L Cells (Cell Line),
pubmed-meshheading:6127625-Membrane Proteins,
pubmed-meshheading:6127625-Mice,
pubmed-meshheading:6127625-P-Glycoprotein,
pubmed-meshheading:6127625-Phenotype,
pubmed-meshheading:6127625-Transformation, Genetic
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pubmed:year |
1982
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pubmed:articleTitle |
DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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