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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
|
pubmed:dateCreated |
1982-12-21
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pubmed:abstractText |
The N-gamma-glutamyl derivatives of L-thiazolidine-4-carboxylic acid, 4-aminobutyric acid, 1-aminocyclopentanecarboxylic acid, 2-aminophenol, and p-fluoro-L-phenylalanine (compounds 6, 8, 9, 10, and 12, respectively) were synthesized using the synthon phthaloylglutamic anhydride. Their relative rates of cleavage by the enzyme gamma-glutamyl transpeptidase (gamma-GT) were determined in order to evaluate the possibility for their selective release by this enzyme which is elevated in certain pathological conditions. Compounds 6, 8, and 9 were not readily solvolyzed by gamma-GT, but compounds 10 and 12, as well as the N-gamma-glutamylated derivatives of 3- and 4-aminophenol, were readily cleaved.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0022-2623
|
pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1018-21
|
pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading | |
pubmed:year |
1982
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pubmed:articleTitle |
Drug latentiation by gamma-glutamyl transpeptidase.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
|