Linked Life Data

6127014

Source:http://linkedlifedata.com/resource/pubmed/id/6127014

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-12-2
pubmed:abstractText
Quercetin protects mice from lethal Mengo M virus infection when given orally 12 and 1 hr before and 8, 24, 36, 48 and 56 hr after inoculation. No differences in the course of infection have been found between normal splenectomized or congenitally athymic mice. Likewise the effect of drug treatment was similar in all three models. Necrotic lesions in the main target organs (central nervous system, salivary and lacrimal glands, thymus, pancreas, kidneys and spleen) from both normal and immunodeficient animals were less severe and developed later in quercetin-treated mice than in placebo-treated ones. In a few quercetin-treated virus-infected survivors a slight and persistent encephalitis was seen. Quercetin enhanced the graft-versus-host reaction, but failed to affect the humoral antibody response of mice to sheep red blood cells. It is concluded that T- and B-lymphocytes seem involved neither in the pathogenesis of acute Mengo virus infection nor in the antiviral effect of quercetin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0001-723X
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
148-55
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Effect of quercetin on the course of mengo virus infection in immunodeficient and normal mice. A histologic study.
pubmed:publicationType
Journal Article