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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1982-10-21
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pubmed:abstractText |
Pharmacology is the study of the properties of a drug with respect to its interaction with the host, toxicology, and with the disease, therapeutics. Since both the toxicology and therapeutic activity of L-asparaginase are presented by others at this symposium, I will give only a brief overview of the pharmacology of L-asparaginase with particular reference to how it differs from other chemotherapeutic agents. Primarily, I would like to discuss how it may be possible to modify some of the pharmacological constraints on the therapeutic responses to L-asparaginase by combining the enzyme with inhibitors of asparagine synthetase and by using polymer-modified forms of the enzyme.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0361-5960
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
65 Suppl 4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
47-55
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6125260-Animals,
pubmed-meshheading:6125260-Asparaginase,
pubmed-meshheading:6125260-Asparagine,
pubmed-meshheading:6125260-Aspartate-Ammonia Ligase,
pubmed-meshheading:6125260-Cell Line,
pubmed-meshheading:6125260-Drug Resistance,
pubmed-meshheading:6125260-Drug Therapy, Combination,
pubmed-meshheading:6125260-Female,
pubmed-meshheading:6125260-Half-Life,
pubmed-meshheading:6125260-Leukemia L5178,
pubmed-meshheading:6125260-Liver,
pubmed-meshheading:6125260-Male,
pubmed-meshheading:6125260-Mice,
pubmed-meshheading:6125260-Neoplasm Transplantation,
pubmed-meshheading:6125260-Polymers,
pubmed-meshheading:6125260-Structure-Activity Relationship
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pubmed:year |
1981
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pubmed:articleTitle |
Pharmacology of L-asparaginase and the effects of host and enzyme modification.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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