Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-10-29
pubmed:abstractText
1 Plasma levels of atenolol and metoprolol and their effects on exercise heart rate have been studied after oral administration of single doses of 100 mg of the two drugs in ordinary tablets alone and during concomittant cimetidine medication of 1 g per day. 2 Cimetidine caused no significant changes in the bioavailability of any of the two beta-adrenoceptor blockers and the rate of elimination of metoprolol was unaffected by the histamine H2-receptor blocker. A slight but significant increase in the elimination half-life from 6.5 +/- 0.6 to 7.9 +/- 0.6 (P less than 0.05) was noted for atenolol after pretreatment with cimetidine. The beta-adrenoceptor blocking effect was about the same for the used doses of atenolol and metoprolol and it was not changed during cimetidine therapy.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-1079686, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-27019, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-456431, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-6102500, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-6115283, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-650423, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-6767973, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-6786672, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-6788056, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-7002420, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-7274054, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-7391176, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-7406377, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-7453751, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-7464861, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-872491, http://linkedlifedata.com/resource/pubmed/commentcorrection/6125199-89387
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0306-5251
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-72
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The effect of pretreatment with cimetidine on the bioavailability and disposition of atenolol and metoprolol.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial