Linked Life Data

6124546

Source:http://linkedlifedata.com/resource/pubmed/id/6124546

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-9-10
pubmed:abstractText
1 After ganglionic blockade and bilateral vagotomy, vasopressor responses induced by activation of postsynaptic alpha 1- and alpha 2-adrenoreceptors were elicited in the intact circulatory system of rabbits. 2 The hypertensive effects of the selective stimulating agents methoxamine (alpha 1-agonist) and B-HT 920 (alpha 2-agonist) were effectively antagonized by the adrenoreceptor antagonists prazosin and yohimbine, respectively. These findings confirm the existence of two types of postsynaptic alpha-adrenoreceptors (alpha 1- and alpha 2-type) in vascular smooth muscle of rabbits. 3 The calcium antagonistic drug nifedipine did not affect the maximal increase in diastolic pressure brought about by methoxamine, whereas it strongly inhibited the hypertensive effects of B-HT 920. 4 It is concluded that this confirmation of the selective inhibition of postjunctional alpha 2-adrenoreceptor-mediated vasopressor responses by a calcium antagonistic drug, such as nifedipine, indicates that this activity constitutes a general phenomenon. This finding supports the hypothesis that an influx of extracellular calcium is necessary for the vasoconstriction mediated by postsynaptic alpha 2-adrenoreceptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0144-1795
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-20
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Impairment by nifedipine of vasopressor responses to stimulation of postsynaptic alpha 2-adrenoreceptors in ganglion--blocked rabbits. Further evidence for the selective inhibition of postsynaptic alpha 2-adrenoreceptor-induced pressor responses by calcium antagonists.
pubmed:publicationType
Journal Article