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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1982-8-26
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pubmed:abstractText |
In the isolated guinea-pig right atria and tracheal strips, both propranolol and YM-09538 caused a parallel shift of the dose-response curve for isoproterenol to the right, indicating that these two drugs block nonselectively the beta 1 1- and beta 2-adrenoceptors. Propranolol potentiated the histamine-induced bronchoconstriction in the anesthetized dogs, whereas YM-09538 did not affect the histamine-induced bronchoconstriction. Propranolol degranulated the isolated rat mesenteric mast cells in contrast to YM-09538 which had no significant effect on mast cells. Neither propranolol nor YM-09538 affected the hapten specific IgE antibody response in female BDF1 mice. These results suggest that YM-09538 has a much lesser effect on airway function than propranolol.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0301-4533
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
256
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97-107
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6124220-Adrenergic alpha-Antagonists,
pubmed-meshheading:6124220-Adrenergic beta-Antagonists,
pubmed-meshheading:6124220-Airway Obstruction,
pubmed-meshheading:6124220-Airway Resistance,
pubmed-meshheading:6124220-Animals,
pubmed-meshheading:6124220-Antibody Formation,
pubmed-meshheading:6124220-Cromolyn Sodium,
pubmed-meshheading:6124220-Dogs,
pubmed-meshheading:6124220-Ethanolamines,
pubmed-meshheading:6124220-Female,
pubmed-meshheading:6124220-Guinea Pigs,
pubmed-meshheading:6124220-Immunoglobulin E,
pubmed-meshheading:6124220-Isoproterenol,
pubmed-meshheading:6124220-Male,
pubmed-meshheading:6124220-Mast Cells,
pubmed-meshheading:6124220-Mice,
pubmed-meshheading:6124220-Mice, Inbred Strains,
pubmed-meshheading:6124220-Propranolol,
pubmed-meshheading:6124220-Rats,
pubmed-meshheading:6124220-Rats, Inbred Strains
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pubmed:year |
1982
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pubmed:articleTitle |
Comparison of airway obstruction induced by propranolol and YM-09538 (a combined alpha- and beta-adrenoceptor blocking drug).
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
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