| pubmed-article:6124000 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6124000 | lifeskim:mentions | umls-concept:C0000742 | lld:lifeskim |
| pubmed-article:6124000 | lifeskim:mentions | umls-concept:C0040100 | lld:lifeskim |
| pubmed-article:6124000 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6124000 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:6124000 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:6124000 | pubmed:dateCreated | 1982-8-14 | lld:pubmed |
| pubmed-article:6124000 | pubmed:abstractText | Abelson murine leukemia virus (A-MuLV) is derived from the thymotropic Moloney leukemia virus. However, injection of mice with A-MuLV by conventional routes results in rapidly arising peripheral and bone marrow lymphomas, not thymomas or T cell tumors. In this study thymomas have been induced by intrathymic injection of A-MuLV into BALB/c and C57BL/Ka mice. In both strains thymomas arose with short latent periods, comparable with the latencies of nonthymic tumors induced by intraperitoneal injection of A-MuLV and significantly shorter than those of thymomas induced by intrathymic injection of Moloney leukemia virus. Cells of the BALB/c thymomas were predominantly Thy-1-; those of C57BL/Ka thymomas were predominantly Thy-1+. Tissue culture lines were established and cloned. Some of these expressed low amounts of Thy-1 and one also expressed Lyt-1. Virus from cloned lines transformed 3T3 cells in vitro and induced Abelson disease in vivo when injected intraperitoneally into neonates. The A-MuLV p120 protein has been precipitated from metabolically labeled cell lysates of one cloned Thy-1+ line. These results show that A-MuLV can transform cells in the T lymphocyte lineage. | lld:pubmed |
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| pubmed-article:6124000 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6124000 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6124000 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6124000 | pubmed:month | May | lld:pubmed |
| pubmed-article:6124000 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6124000 | pubmed:author | pubmed-author:FilaKK | lld:pubmed |
| pubmed-article:6124000 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6124000 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:6124000 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6124000 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6124000 | pubmed:pagination | 2917-21 | lld:pubmed |
| pubmed-article:6124000 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6124000 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6124000 | pubmed:articleTitle | Rapid thymomas induced by Abelson murine leukemia virus. | lld:pubmed |
| pubmed-article:6124000 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6124000 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6124000 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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