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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1982-8-14
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pubmed:abstractText |
Abelson murine leukemia virus (A-MuLV) is derived from the thymotropic Moloney leukemia virus. However, injection of mice with A-MuLV by conventional routes results in rapidly arising peripheral and bone marrow lymphomas, not thymomas or T cell tumors. In this study thymomas have been induced by intrathymic injection of A-MuLV into BALB/c and C57BL/Ka mice. In both strains thymomas arose with short latent periods, comparable with the latencies of nonthymic tumors induced by intraperitoneal injection of A-MuLV and significantly shorter than those of thymomas induced by intrathymic injection of Moloney leukemia virus. Cells of the BALB/c thymomas were predominantly Thy-1-; those of C57BL/Ka thymomas were predominantly Thy-1+. Tissue culture lines were established and cloned. Some of these expressed low amounts of Thy-1 and one also expressed Lyt-1. Virus from cloned lines transformed 3T3 cells in vitro and induced Abelson disease in vivo when injected intraperitoneally into neonates. The A-MuLV p120 protein has been precipitated from metabolically labeled cell lysates of one cloned Thy-1+ line. These results show that A-MuLV can transform cells in the T lymphocyte lineage.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-163444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-167514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-178822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-209468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-212198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-228287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-397920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-398327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-4099080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-4355680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-4540455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-4625122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-4918190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-6254050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-6772961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-6969856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-702054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-7388941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-7410844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-90660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6124000-95182
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2917-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6124000-Abelson murine leukemia virus,
pubmed-meshheading:6124000-Animals,
pubmed-meshheading:6124000-Antigens, Surface,
pubmed-meshheading:6124000-Antigens, Thy-1,
pubmed-meshheading:6124000-Cell Line,
pubmed-meshheading:6124000-Cell Transformation, Viral,
pubmed-meshheading:6124000-Female,
pubmed-meshheading:6124000-Leukemia Virus, Murine,
pubmed-meshheading:6124000-Male,
pubmed-meshheading:6124000-Mice,
pubmed-meshheading:6124000-Neoplasms, Experimental,
pubmed-meshheading:6124000-Thymoma,
pubmed-meshheading:6124000-Thymus Neoplasms,
pubmed-meshheading:6124000-Virus Replication
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pubmed:year |
1982
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pubmed:articleTitle |
Rapid thymomas induced by Abelson murine leukemia virus.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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