Linked Life Data

6123430

Source:http://linkedlifedata.com/resource/pubmed/id/6123430

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-8-14
pubmed:abstractText
To determine whether the insulinotropic effects of dopamine were mediated through the adrenergic system, dogs were infused with dopamine before or after various combinations of adrenergic and cholinergic blockade. Plasma glucose levels did not change significantly throughout the individual experiments, although cardiovascular effects from both blockade and dopamine infusion were demonstrated. The pronounced in vivo insulinotropic effects of dopamine were abolished by beta-adrenergic blockade with propranolol and all subsequent combinations of propranolol, phentolamine, and atropine. These results contrast with the in vitro suppression of insulin by dopamine, which is abolished by alpha-adrenergic blockade by phentolamine. Therefore, it may be concluded that the prevention of dopamine effects on insulin secretion by adrenergic antagonism is evidence that dopamine exerts its effects on the B cell directly or indirectly through the adrenergic system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
111
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
214-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Abolition of dopaminergic insulin secretion by beta-adrenergic antagonism.
pubmed:publicationType
Journal Article