Linked Life Data

6123097

Source:http://linkedlifedata.com/resource/pubmed/id/6123097

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-7-8
pubmed:abstractText
The release of vasoactive intestinal peptide (VIP) from rat brain cortical and amygdala slices was studied by using various depolarizing agents such as potassium (K+), veratridine (VER) and batrachotoxin (BTX). The basal release of VIP observed is of the same order of magnitude for both structures and represents less than 0.1% of the tissue content per minute measured by a specific radioimmunoassay. Maximal stimulation obtained with 56 mMK+, 50 microM VER and 1 microM BTX corresponds to a mean 3-fold increase above the basal release of VIP in both cortex and amygdala. When the incubation medium did not contain any calcium, the action of potassium on the release of VIP was suppressed. When tetrodotoxin (1 microM) was added to the incubation medium, the veratridine- and batrachotoxin-induced release of VIP was inhibited whereas K+-induced release was unaffected. These results support the hypothesis that VIP can be a neurotransmitter in the central nervous system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Release of vasoactive intestinal peptide from rat brain slices by various depolarizing agents.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't