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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1982-5-27
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pubmed:abstractText |
As one index of sympathetic reactivity, electrodermal responses (EDR) were evoked from central (hypothalamic) and peripheral (ulnar nerve) sites in pentobarbital-anesthetized cats. When compared with intravenous chlorpromazine (ED50 approximately 1.0 mg/kg), only thioridazine, trifluoperazine, and pimozide were less potent than chlorpromazine in reducing the amplitude of these centrally-evoked sympathetic-cholinergic responses. Perphenazine and methotrimeprazine (a non-neuroleptic phenothiazine) were about twice as potent as chlorpromazine. Haloperidol and triflupromazine were about 5 times as potent and chlorprothixine was more than 10 times as potent. None of these agents reduced the peripherally-evoked electrodermal response, indicating a CNS mode of action. Diazepam was without effect at either site. In addition, pretreatment with yohimbine (0.5 mg/kg. i.v.) did not significantly alter the ED50 for any of the above drugs. These results demonstrate that all of the phenothiazines and non-phenothiazine neuroleptics tested produce a dose-dependent central sympatho-inhibition and that diazepam does not. The results also suggest that there is no significant correlation between central sympatho-inhibition and the antipsychotic potency of these compounds and that their depression of central sympathetic outflow is independent of alpha-adrenergic mechanisms in the CNS.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antipsychotic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Atropine,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorpromazine,
http://linkedlifedata.com/resource/pubmed/chemical/Diazepam,
http://linkedlifedata.com/resource/pubmed/chemical/Psychotropic Drugs
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0028-3908
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
73-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6121301-Animals,
pubmed-meshheading:6121301-Antipsychotic Agents,
pubmed-meshheading:6121301-Atropine,
pubmed-meshheading:6121301-Cats,
pubmed-meshheading:6121301-Central Nervous System,
pubmed-meshheading:6121301-Chlorpromazine,
pubmed-meshheading:6121301-Diazepam,
pubmed-meshheading:6121301-Electrophysiology,
pubmed-meshheading:6121301-Female,
pubmed-meshheading:6121301-Male,
pubmed-meshheading:6121301-Peripheral Nerves,
pubmed-meshheading:6121301-Psychotropic Drugs,
pubmed-meshheading:6121301-Skin,
pubmed-meshheading:6121301-Skin Physiological Phenomena,
pubmed-meshheading:6121301-Sympathetic Nervous System
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pubmed:year |
1982
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pubmed:articleTitle |
A quantitative assessment of CNS sympatho-inhibition produced by psychotropic drugs.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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