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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1982-4-20
|
| pubmed:abstractText |
The properties of tick-borne encephalitis (TBE) virus persisting for 90-383 days after intracerebral and subcutaneous inoculation of Macaca rhesus monkeys were studied, namely (1) the type of infection produced directly in the tissues of the experimental monkeys; (2) the activating effect of co-cultivation and explantation procedures; and (3) the phenotype of the isolates by a set of markers. The virus was detected and analysed in 52 instances. Directly in monkey tissues the virus induced a productive infection rarely (5.8%) but more frequently (71.2%) an abortive infection detectable by immunofluorescence (presence of virus-specific antigen). In 23% of instances a nonproductive infection was observed in monkey tissues. Like abortive infection it could be activated by the co-cultivation of cells and explantation procedures. The latter exerted a more marked activating effect than co-cultivation. The strains isolated from monkey tissues in productive infection or activated by explanation or co-cultivation were heterogeneous in their properties. The following virus phenotypes were found: virus highly virulent for mice, cytocidal and antigenically complete; a cytocidal virus of low virulence, possessing haemagglutinin; and a cytocidal virus apathogenic for mice, devoid of haemagglutinin but synthesizing complement-fixing antigen and an antigen detectable by immunofluorescence.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0001-723X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
352-60
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6120636-Animals,
pubmed-meshheading:6120636-Antigens, Viral,
pubmed-meshheading:6120636-Chick Embryo,
pubmed-meshheading:6120636-Cytopathogenic Effect, Viral,
pubmed-meshheading:6120636-Encephalitis, Tick-Borne,
pubmed-meshheading:6120636-Encephalitis Viruses, Tick-Borne,
pubmed-meshheading:6120636-Hemagglutinins, Viral,
pubmed-meshheading:6120636-Macaca,
pubmed-meshheading:6120636-Macaca mulatta,
pubmed-meshheading:6120636-Mice,
pubmed-meshheading:6120636-Phenotype,
pubmed-meshheading:6120636-Virus Activation,
pubmed-meshheading:6120636-Virus Cultivation
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
Persistence of tic-borne encephalitis virus in monkeys. III. Phenotypes of the persisting virus.
|
| pubmed:publicationType |
Journal Article
|