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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4531
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pubmed:dateCreated |
1982-4-12
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pubmed:abstractText |
In the guinea pig ileum myenteric plexus--longitudinal muscle preparation, dynorphin-(1--13) and the prototypical kappa agonist ethylketocyclazocine had equally poor sensitivity to naloxone antagonism and showed selective cross protection in receptor inactivation experiments with the alkylating antagonist beta-chlornaltrexamine. In binding assays with membranes from guinea pig brain, ethylketocyclazocine and dynorphin-(1--13) amide were more potent in displacing tritium-labeled ethylketocyclazocine than in displacing typical mu and delta opioid receptor ligands. In the two preparations studied, the dynorphin receptor appears to be the same as the kappa opioid receptor.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclazocine,
http://linkedlifedata.com/resource/pubmed/chemical/Dynorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Endorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Leucine,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/Ethylketocyclazocine,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine Derivatives,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/dynorphin (1-13),
http://linkedlifedata.com/resource/pubmed/chemical/normorphine
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
215
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
413-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6120570-Analgesics, Opioid,
pubmed-meshheading:6120570-Animals,
pubmed-meshheading:6120570-Binding, Competitive,
pubmed-meshheading:6120570-Brain,
pubmed-meshheading:6120570-Cyclazocine,
pubmed-meshheading:6120570-Dynorphins,
pubmed-meshheading:6120570-Endorphins,
pubmed-meshheading:6120570-Enkephalin, Leucine,
pubmed-meshheading:6120570-Enkephalins,
pubmed-meshheading:6120570-Ethylketocyclazocine,
pubmed-meshheading:6120570-Guinea Pigs,
pubmed-meshheading:6120570-Ligands,
pubmed-meshheading:6120570-Morphine Derivatives,
pubmed-meshheading:6120570-Myenteric Plexus,
pubmed-meshheading:6120570-Naloxone,
pubmed-meshheading:6120570-Peptide Fragments,
pubmed-meshheading:6120570-Receptors, Opioid
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pubmed:year |
1982
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pubmed:articleTitle |
Dynorphin is a specific endogenous ligand of the kappa opioid receptor.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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