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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1982-4-20
|
| pubmed:abstractText |
A series of gamma-methyl- (5) and alpha-methyl(aryloxy)propanolamines (6) were synthesized and evaluated for beta-adrenergic blocking action. The binding constant (KD) was determined for compounds 5a-j on cultured C6-2B astrocytoma cells. Compounds 5a-j and 6a-e were evaluated for beta 1-antagonist action on guinea pig atria and beta 2-antagonist action on guinea pig tracheal strips. Several gamma-methyl(aryloxy)propanolamines showed affinity for beta receptors and a possible preference for beta 2 receptors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1211-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6120233-Adrenergic beta-Antagonists,
pubmed-meshheading:6120233-Animals,
pubmed-meshheading:6120233-Guinea Pigs,
pubmed-meshheading:6120233-Heart,
pubmed-meshheading:6120233-Propanolamines,
pubmed-meshheading:6120233-Receptors, Adrenergic, beta,
pubmed-meshheading:6120233-Structure-Activity Relationship,
pubmed-meshheading:6120233-Trachea
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
beta-Adrenergic blocking agents. alpha- and gamma-methyl(aryloxy)propanolamines.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|