Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-4-12
pubmed:abstractText
Escherichia coli heat-stable enterotoxin (ST) appears to cause intestinal fluid secretion by activating intestinal particulate guanylate cyclase. Recent studies suggest that chlorpromazine and quinacrine reduce the intestinal secretory response to ST and activation of guanylate cyclase by ST. We have examined the effects of lanthanum chloride, another agent that has been shown to inhibit calcium-dependent cellular processes, on the intestinal secretory response to ST and on the inhibition of ST by chlorpromazine and quinacrine. Lanthanum (2.5 to 10 mumol per mouse) reduced ST-mediated intestinal fluid secretion in the suckling mouse assay by 40 to 56%, respectively, but did not reduce basal fluid accumulation or ST activation of particulate guanylate cyclase. Intestinal fluid secretion in suckling mice induced by 8-bromocyclic GMP was also reduced by lanthanum. When subeffective doses of lanthanum and chlorpromazine were combined, they blocked both ST- and 8-bromocyclic GMP-mediated gut secretion in suckling mice. Likewise, the combination of subeffective doses of lanthanum and quinacrine reduced ST-mediated gut secretion in suckling mice. However, 8-bromocyclic GMP-induced secretion was not synergistically inhibited by lanthanum and quinacrine. These results suggest that lanthanum blocks ST-induced secretion after ST activation of guanylate cyclase. Additionally, lanthanum potentiates the inhibitory effects of quinacrine and chlorpromazine on ST and suggests that combination antisecretory therapy deserves further exploration.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-16208, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-164410, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-177461, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-197323, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-203862, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-227248, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-26915, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-346481, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-381206, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-393625, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-4102271, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-4334491, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-4337121, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-4401974, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-4553083, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-4578157, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-5018378, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-6106030, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-6107277, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-780280, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-817726, http://linkedlifedata.com/resource/pubmed/commentcorrection/6120140-84263
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
483-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Lanthanum chloride inhibition of the secretory response to Escherichia coli heat-stable enterotoxin.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't