Linked Life Data

6119779

Source:http://linkedlifedata.com/resource/pubmed/id/6119779

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1982-3-26
pubmed:abstractText
The effect of oral ranitidine 150 mg on the acid and pepsin response to sham feeding or pentagastrin was examined in healthy volunteers in a double-blind randomized trial. Gastric juice was collected up to 255 min after ingestion of the drug. In placebo treated subjects, basal acid secretion rate and the secretion rate following sham feeding and injection of 6 micrograms kg-1 of pentagastrin were 5.3 +/- 2.0 S.E.M., 12.3 +/- 3.2, and 24.4 +/- 5.4 mmol h-1, respectively. The corresponding values in ranitidine treated subjects were 0.1 +/- 0.1, 0.5 +/- 0.2, and 3.4 +/- 1.2, respectively. The reduction of acid secretion in all three instances is statistically significant (p less than 0.025, p less than 0.05, and p less than 0.05, respectively). Basal, sham feeding stimulated, and pentagastrin stimulated pepsin secretion rates in the placebo treated group were 38.4 +/- 7.0 S.E.M., 68.6 +/- 13.2, and 39.2 +/- 8.0 mg h-1, respectively. In the ranitidine treated group, the values were 5.0 +/- 3.4, 13.2 +/- 5.6, and 19.6 +/- 6.0, respectively. The reduction of pepsin secretion during basal state and following sham feeding is statistically significant (p less than 0.005 and p less than 0.01). Thus, oral ranitidine inhibits the acid and pepsin response to sham feeding in man. Its inhibitory effect on the acid response to pentagastrin lasts for at least 4 h.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0085-5928
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-31
pubmed:dateRevised
2008-2-13
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Effect of ranitidine on gastric acid and pepsin secretion following sham feeding.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't