Linked Life Data

6119747

Source:http://linkedlifedata.com/resource/pubmed/id/6119747

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-3-26
pubmed:abstractText
The present study investigated the mechanisms of the action of a tricyclic antidepressant, desmethylimipramine, upon paradoxical sleep in the rat in acute administration. Desmethylimipramine induces an increase in paradoxical sleep latency, as well as a decrease of its total duration; these two modifications are dose-dependent. Different mechanisms may be evoked: inhibition of catecholamine synthesis, inhibition of locus coeruleus by adrenergic collaterals, or an anticholinergic effect. The results show that inhibition of synthesis is not quantitatively sufficient to induce the observed effects. It appears more probable that this decrease in paradoxical sleep results from a collateral inhibition, with the possible participation of an anticholinergic effect. The contributions of these different factors are discussed.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0370-4475
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
228-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
[Decrease of paradoxical sleep in the rat under tricyclic antidepressant: the role of collateral inhibition (author's transl)].
pubmed:publicationType
Journal Article, English Abstract