Linked Life Data

61166

Source:http://linkedlifedata.com/resource/pubmed/id/61166

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1976-12-1
pubmed:abstractText
Antibody against Ia antigens inhibits the ability of B lymphocytes to bind aggregated immunoglobulin and to form EA rosettes. The explanation suggested for this phenomenon has been that Ia antigens are identical to or closely associated with Fc receptors. But a variety of observations preclude acceptance of this explanation since inhibition is also demonstrable with antibody against a wide variety of B cell surface components, including H-2K, H-2D, beta2 microglobulin, immunoglobulin, Ly 4.2. Furthermore, Fc receptor function can be separated from Ia antigens by capping or by isolation of membrane components. It seems likely that the mechanism of inhibition of Fc receptors by antibody against Ia antigens is part of a broader spectrum of effects induced when antibody binds to cell membrane antigens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0090-0877
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
243-61
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Fc receptors and Ia antigens.
pubmed:publicationType
Journal Article, Review