Linked Life Data

6116284

Source:http://linkedlifedata.com/resource/pubmed/id/6116284

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1981-11-18
pubmed:abstractText
A primary event in the stimulation of cyclic AMP-mediated active Cl secretion across epithelial tissues is an increase in the Cl permeability of the apical cell membrane. A rapid reduction in apical cell membrane resistance to Cl movement permits Cl to leave the cell down its electrochemical potential difference across this barrier. Since cell Cl activity is not markedly influenced by changes in the rate of Cl secretion, the cyclic nucleotide may also increase the ease with which Cl gains access to the secretory cells across the basolateral membrane. This Cl entry process appears to be mediated by NaCl co-transport since the maintenance of a high cell Cl activity depends upon the presence of sodium in the serosal bathing solution. Increased Cl entry across the basolateral membrane would promote enhanced Na entry into the cell and a secondary stimulation of active Na extrusion from cell to serosal solution. Increased Na-K-pump activity and/or a change in the K permeability of the basolateral membrane may be responsible for the augmented conductive ion flow across this barrier which accompanies the stimulation of active Cl secretion.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0094-7733
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
137-45
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Electrophysiology of chloride-secreting epithelia.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't