Linked Life Data

6115372

Source:http://linkedlifedata.com/resource/pubmed/id/6115372

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1981-10-14
pubmed:abstractText
Aggressive behavior in the footshock induced fighting test (FIFT) was studied after treatment with benzodiazepines (diazepam, nitrazepam, temazepam, medazepam) given alone or in combination with beta-adrenoreceptor antagonists (propranolol, oxprenolol, practolol). With the combinations of those drugs it was found that diazepam (0.5 mg/kg) with propranolol, oxprenolol, and practolol (20 mg/kg); nitrazepam (0.25 mg/kg) with propranolol (10 mg/kg) and nitrazepam (0.1 mg/kg) with practolol (20 mg/kg); temazepam (0.5 mg/kg) with propranolol (10 mg/kg) and temazepam (1 mg/kg) with oxprenolol and practolol (20 mg/kg); medazepam (1.5 mg/kg) with propranolol (10.mg/kg) and medazepam (1 mg/kg) with practolol (20 mg/kg) produced a statistically significant decrease in frequency of fighting episodes in mice as compared with benzodiazepines alone and with control animals. The results demonstrate that beta-adrenoreceptor antagonists potentiate the antiaggressive action of benzodiazepines when given in doses which by themselves do not suppress aggression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-0244
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
731-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
Beta-adrenoreceptor antagonists enhance the benzodiazepine-induced suppression of footshock induced fighting in mice.
pubmed:publicationType
Journal Article