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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1981-8-10
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pubmed:abstractText |
Recent studies are described concerning the physiological role and tissue distribution of Protein I, a synapse-specific phosphoprotein. This protein is present in both the central and the peripheral nervous system and appears to be enriched in synaptic vesicles. It is a major substrate for both Ca2(-)- and cyclic AMP-dependent phosphorylation in the brain. In slices of the facial motor nucleus from rat brainstem, serotonin (5-HT) added to the incubation medium stimulates the phosphorylation of Protein I. This effect is potentiated by low concentrations of isobutylmethylxanthine and is prevented by the serotonin antagonist mianserin.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0091-3057
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-74
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6113600-Animals,
pubmed-meshheading:6113600-Cyclic AMP,
pubmed-meshheading:6113600-Mianserin,
pubmed-meshheading:6113600-Nerve Tissue Proteins,
pubmed-meshheading:6113600-Nervous System,
pubmed-meshheading:6113600-Neurons,
pubmed-meshheading:6113600-Neurotransmitter Agents,
pubmed-meshheading:6113600-Phosphorylation,
pubmed-meshheading:6113600-Serotonin,
pubmed-meshheading:6113600-Synapses,
pubmed-meshheading:6113600-Synapsins,
pubmed-meshheading:6113600-Synaptic Membranes
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pubmed:year |
1980
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pubmed:articleTitle |
Neuronal protein phosphorylation: recent studies concerning protein I, a synapse-specific phosphoprotein.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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