Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1981-7-20
|
| pubmed:abstractText |
The autoradiographic identification of chemically-induced, unscheduled DNA synthesis in primary cultures of adult rat hepatocytes is currently being validated as a predictive test for mutagens/carcinogens. Of 8 antihistaminic drugs tested, 2, pyrilamine maleate and tripelennamine HCl, were positive for unscheduled DNA synthesis. Further investigation of the mutagenic/carcinogenic potential of these compounds in alternate test systems is suggested.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0304-3835
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
67-73
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6112061-Animals,
pubmed-meshheading:6112061-Autoradiography,
pubmed-meshheading:6112061-Carcinogens,
pubmed-meshheading:6112061-DNA,
pubmed-meshheading:6112061-Dose-Response Relationship, Drug,
pubmed-meshheading:6112061-Histamine H1 Antagonists,
pubmed-meshheading:6112061-Liver,
pubmed-meshheading:6112061-Rats
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
The induction of unscheduled DNA synthesis by antihistamines in primary hepatocyte cultures.
|
| pubmed:publicationType |
Journal Article
|