Linked Life Data

6110324

Source:http://linkedlifedata.com/resource/pubmed/id/6110324

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1981-4-24
pubmed:abstractText
Two groups of hamsters maintained on eight high (25.6%) or low (5.3%) content protein diets were infected with 50 Opisthorchis viverrini metacercariae by intragastric inoculation. Three animals from each group were sacrificed at 14-day intervals over a 32-week period. Two groups of non-infected control animals maintained on identical diets were killed at similar intervals. Histological examination revealed qualitatively similar pathological responses to the parasite in both diet groups, but overall the low protein diet group had the more severe lesions. Two weeks after infection, second order bile ducts showed epithelial focal necrosis, reactive hyperplasia and folding of the bile duct epithelium with some periductal fibrosis. Periductal inflammatory cells were predominantly eosinophils and lymphocytes at this time, changing after six weeks to predominantly lymphoblast and plasma cell infiltrates. Central bile ducts showed maximal concentric fibrosis at 12 weeks and this was considerably more pronounced in high protein fed animals. The small peripheral bile ductules proliferated and by four weeks post-infection, adjacent portal tracts appeared linked together, until at eight weeks some of the livers were nodular. The degree of bile ductule proliferation was markedly more pronounced in the low protein fed animals such that by 12 weeks parts of the peripheral liver substance was obliterated by proliferating ductules. No tumours or evidence of premalignant lesions were detected in livers from any of the infected animals, but it is likely that the infection period was rather too short for malignant transformation to ensue. The possible pathogenetic mechanisms operating in this animal model of opisthorchiasis are discussed with particular reference to the disease in man.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0001-706X
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
337-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Opisthorchis viverrini: liver changes in golden hamsters maintained on high and low protein diets.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't