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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5800
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pubmed:dateCreated |
1981-4-24
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pubmed:abstractText |
The HLA-A and -B antigens, encoded in the major histocompatibility complex, are transmembrane proteins whose carboxy termini project inwards from the cell membrane. The intracellular region of the HLA-B7 antigen is known to include two glutamine residues. We have used guinea pig transglutaminase to show that in vitro the enzyme couples amines specifically to glutamine residues in the carboxy-terminal region of the HLA-B7 and -A2 antigens. The specificity of this reaction has an immediate practical significance, but may also have a wider biological interest.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Putrescine,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Glutamyltransferase
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0028-0836
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
289
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
819-21
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading | |
pubmed:year |
1981
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pubmed:articleTitle |
Transglutaminase modifies the carboxy-terminal intracellular region of HLA-A and -B antigens.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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