| pubmed-article:6109636 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6109636 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:6109636 | lifeskim:mentions | umls-concept:C1267092 | lld:lifeskim |
| pubmed-article:6109636 | lifeskim:mentions | umls-concept:C0227365 | lld:lifeskim |
| pubmed-article:6109636 | lifeskim:mentions | umls-concept:C0027740 | lld:lifeskim |
| pubmed-article:6109636 | lifeskim:mentions | umls-concept:C0042395 | lld:lifeskim |
| pubmed-article:6109636 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:6109636 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:6109636 | lifeskim:mentions | umls-concept:C1707723 | lld:lifeskim |
| pubmed-article:6109636 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:6109636 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:6109636 | pubmed:dateCreated | 1981-4-24 | lld:pubmed |
| pubmed-article:6109636 | pubmed:abstractText | Vasoactive intestinal polypeptide (VIP), located within intrinsic neurones of the guinea-pig taenia coli, has been proposed as a neurotransmitter which may mediate certain non-adrenergic, non-cholinergic effects within the gastrointestinal tract. The relaxation of the taenia coli produced by exogenous VIP has a longer latency and time to maximum than the relaxation which is obtained during electrical stimulation of the non-adrenergic, non-cholinergic nerves. The responses to exogenous VIP (0.03-1 microM) were abolished by the proteolytic enzyme alpha-chymotrypsin (1 U/ml), whereas there were no statistically significant changes in the inhibitory responses to intramural nerve stimulation (0.1-5 Hz) or exogenous ATP (0.03-100 microM), which closely mimics the nerve-mediated response. Apamin is a neurotoxin which prevents the increase in K+ conductance associated with the inhibitory junction potential produced by stimulation of the non-adrenergic, non-cholinergic inhibitory nerves. In the presence of apamin (0.005-1 microM) the responses to intramural nerve stimulation and exogenous ATP were significantly antagonised, and often converted to contractile responses. The VIP-induced relaxations during apamin treatment were not significantly decreased. These results suggest that VIP is unlikely to be the transmitter released from the non-adrenergic, non-cholinergic nerves of the guinea-pig taenia coli, and are consistent with the view that these nerves are purinergic in nature. | lld:pubmed |
| pubmed-article:6109636 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6109636 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6109636 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6109636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6109636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6109636 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6109636 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6109636 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:6109636 | pubmed:author | pubmed-author:BurnstockGG | lld:pubmed |
| pubmed-article:6109636 | pubmed:author | pubmed-author:MackenzieII | lld:pubmed |
| pubmed-article:6109636 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6109636 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:6109636 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:6109636 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6109636 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6109636 | pubmed:pagination | 255-64 | lld:pubmed |
| pubmed-article:6109636 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:6109636 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6109636 | pubmed:articleTitle | Evidence against vasoactive intestinal polypeptide being the non-adrenergic, non-cholinergic inhibitory transmitter released from nerves supplying the smooth muscle of the guinea-pig taenia coli. | lld:pubmed |
| pubmed-article:6109636 | pubmed:publicationType | Journal Article | lld:pubmed |
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