Linked Life Data

6109636

Source:http://linkedlifedata.com/resource/pubmed/id/6109636

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1981-4-24
pubmed:abstractText
Vasoactive intestinal polypeptide (VIP), located within intrinsic neurones of the guinea-pig taenia coli, has been proposed as a neurotransmitter which may mediate certain non-adrenergic, non-cholinergic effects within the gastrointestinal tract. The relaxation of the taenia coli produced by exogenous VIP has a longer latency and time to maximum than the relaxation which is obtained during electrical stimulation of the non-adrenergic, non-cholinergic nerves. The responses to exogenous VIP (0.03-1 microM) were abolished by the proteolytic enzyme alpha-chymotrypsin (1 U/ml), whereas there were no statistically significant changes in the inhibitory responses to intramural nerve stimulation (0.1-5 Hz) or exogenous ATP (0.03-100 microM), which closely mimics the nerve-mediated response. Apamin is a neurotoxin which prevents the increase in K+ conductance associated with the inhibitory junction potential produced by stimulation of the non-adrenergic, non-cholinergic inhibitory nerves. In the presence of apamin (0.005-1 microM) the responses to intramural nerve stimulation and exogenous ATP were significantly antagonised, and often converted to contractile responses. The VIP-induced relaxations during apamin treatment were not significantly decreased. These results suggest that VIP is unlikely to be the transmitter released from the non-adrenergic, non-cholinergic nerves of the guinea-pig taenia coli, and are consistent with the view that these nerves are purinergic in nature.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
255-64
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Evidence against vasoactive intestinal polypeptide being the non-adrenergic, non-cholinergic inhibitory transmitter released from nerves supplying the smooth muscle of the guinea-pig taenia coli.
pubmed:publicationType
Journal Article