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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8200
|
pubmed:dateCreated |
1981-1-26
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pubmed:abstractText |
35 children with the heterozygous form of familial hypercholesterolaemia (FH) who were followed for up to 8 years after starting on cholestyramine treatment showed a progressive decrease in compliance with therapy with time, so that only 55% remained on treatment after 6 years and only 48% after 8 years. Long-term compliance was significantly better in those starting treatment before age 10. Plasma-cholesterol was lowered in all children taking cholestyramine: for the group the mean reduction in plasma-cholesterol ranged from 26 to 44% during the years of the study, on a mean cholestyramine dose of around 0.4 g/kg/day. Cholestyramine thus effectively lowers plasma-cholesterol in FH, but for long-term use compliance is a problem in many children.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0140-6736
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
25
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pubmed:volume |
2
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
873-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:6107543-Adolescent,
pubmed-meshheading:6107543-Age Factors,
pubmed-meshheading:6107543-Child,
pubmed-meshheading:6107543-Child, Preschool,
pubmed-meshheading:6107543-Cholesterol,
pubmed-meshheading:6107543-Cholestyramine Resin,
pubmed-meshheading:6107543-Female,
pubmed-meshheading:6107543-Follow-Up Studies,
pubmed-meshheading:6107543-Heterozygote,
pubmed-meshheading:6107543-Humans,
pubmed-meshheading:6107543-Hyperlipoproteinemia Type II,
pubmed-meshheading:6107543-Infant,
pubmed-meshheading:6107543-Lipoproteins, LDL,
pubmed-meshheading:6107543-Male,
pubmed-meshheading:6107543-Patient Compliance,
pubmed-meshheading:6107543-Time Factors
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pubmed:year |
1980
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pubmed:articleTitle |
Long-term follow-up of children with familial hypercholesterolaemia treated with cholestyramine.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|