Linked Life Data

6105951

Source:http://linkedlifedata.com/resource/pubmed/id/6105951

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1980-11-24
pubmed:abstractText
To evaluate the possible cholinergic control of islet hormone secretion, acetylcholine (10 microM) was perfused into the isolated chicken pancreas-duodenum, with perfusate concentrations of 2.8, 14, or 42 mM glucose. Prompt and significant stimulation of insulin, glucagon, and somatostatin secretion was seen when the glucose concentration was 14 mM, and this stimulation was blocked by preinfusion of atropine sulfate (50 microM). Similar stimulation of all three peptides was seen when the perfusate concentration of glucose was 42 mM. When the perfusate glucose concentration was 2.8 mM, the insulin response to acetylcholine was absent and the response by glucagon could not be discerned, perhaps because release was close to maximal. The somatostatin response, however, was only slightly diminished from that seen at higher glucose levels. The B cell response to acetycholine in the chicken was considerably greater than the weak responses seen to high glucose or arginine, suggesting a dominant role for cholinergic control of avian insulin secretion. In addition, the parasympathetic nervous system may also play a role in the secretory control of A- and D cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1065-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Acetylcholine stimulates insulin, glucagon, and somatostatin release in the perfused chicken pancreas.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.