Linked Life Data

6105246

Source:http://linkedlifedata.com/resource/pubmed/id/6105246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8185
pubmed:dateCreated
1980-10-24
pubmed:abstractText
The frequency with which the plateau of stable phase occurs after remission-induction chemotherapy, and the kinetic features of this phase, were evaluated in 127 carefully staged patients with multiple myeloma. 56 patients (44%) entered a stable plateau state, this pattern being most common in patients with stages IA, IIA, and IIIA of the disease, and least likely in those with stages IIB or IIIB, especially those with Bence Jones protein only or Bence Jones protein plus a serum M-component. Tritiated thymidine labelling index (LI) of bone-marrow myeloma cells, polyamine measurements, and in-vitro myeloma stem-cell culture findings all indicated that the plateau phase is a cytokinetically quiescent state, compared with the more active induction and relapse phases. The major implications of these findings include the avoidance of aggressive "cycle active" treatment and discontinuation of maintenance treatment in plateau-phase patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0140-6736
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Reappraisal of plateau phase in myeloma.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.