Linked Life Data

6102778

Source:http://linkedlifedata.com/resource/pubmed/id/6102778

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-6-27
pubmed:abstractText
Experiment 1 reported the effects of the interaction of a fixed 1 min delivery schedule and body weight, using schedule-induced self-injection paradigm, in the rate of acquisition of methadone and heroin. Eighty-one rats were assigned to 100% and 80% reduced body weight conditions with and without a schedule. The findings show that: (a) voluntary heroin and methadone intake was enhanced when a schedule was introduced to animals at 80% but not at 100% body weight; (b) high intake of heroin and methadone was accompanied by increased levels of plasma 11-OHCS. Experiment 2 showed that the high rate of self-injection was due to the interaction of pharmacological properties of opiates and environmental variables rather than to a general increase in activity arising from the deprivation state or the effects of the schedule. The results are discussed in terms of a stress factor arising from an interaction between environmental and pharmacological factors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0033-3158
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
171-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
The interaction of a fixed time food delivery schedule and body weight on self-administration of narcotic analgesics.
pubmed:publicationType
Journal Article