|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3-4
|
|
pubmed:dateCreated |
1985-9-4
|
|
pubmed:abstractText |
ACTH has both short-term (acute) and long-term (chronic) effects to regulate steroid hormone biosynthesis in the adrenal cortex. The acute action of ACTH involves the mobilization of cholesterol and its binding to cytochrome P-450scc. The long-term action of ACTH involves the regulation of synthesis of the various enzymes involved in steroidogenesis. Evidence is presented that cholesterol may have a role to play in this regulatory process as it does in the short-term action of ACTH, consistent with the concept that substrates of specific forms of cytochrome P-450 are frequently able to regulate the synthesis of these specific forms.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0743-5800
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
387-409
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:6100249-Adrenal Cortex,
pubmed-meshheading:6100249-Adrenocorticotropic Hormone,
pubmed-meshheading:6100249-Adrenodoxin,
pubmed-meshheading:6100249-Animals,
pubmed-meshheading:6100249-Cattle,
pubmed-meshheading:6100249-Cells, Cultured,
pubmed-meshheading:6100249-Cholesterol,
pubmed-meshheading:6100249-Cytochrome P-450 Enzyme System,
pubmed-meshheading:6100249-Humans,
pubmed-meshheading:6100249-Lipoproteins,
pubmed-meshheading:6100249-Lipoproteins, LDL,
pubmed-meshheading:6100249-Rats,
pubmed-meshheading:6100249-Steroids
|
|
pubmed:articleTitle |
Lipoproteins and the regulation of adrenal steroidogenesis.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
|
