Linked Life Data

6098873

Source:http://linkedlifedata.com/resource/pubmed/id/6098873

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1985-4-19
pubmed:abstractText
The effects of 7 or 42 48-hourly i.p. injections of 20 micrograms aflatoxin B1 (AFB) on the acetylcholinesterase activity (AChE) in 8 brain areas and the adenohypophysis of the adult male rat were studied. Aflatoxicosis increased adenohypophysial AChE in direct proportion to the duration of intoxication, which also altered the distribution of AChE in the rat brain. With acute treatment, AChE was depressed in the cerebellum and hippocampus while in the chronically dosed rats AChE was drastically elevated in the mesencephalon and amygdala. Results suggest that AFB changes the ACh turnover and hence the cholinergic transmission in the brain and adenohypophysis. This may result in behavioural deficits and/or performance decrements via a disturbance of the hypothalamo-hypophysial axis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
171-4
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Effect of aflatoxicosis on acetylcholinesterase activity in the brain and adenohypophysis of the male rat.
pubmed:publicationType
Journal Article