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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1985-3-20
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pubmed:abstractText |
Sectioning the dorsal afferents to the rat hippocampus led to an 88% decrease in the level of noradrenaline in the dorsal third of the structure, a 62% reduction in the medial region and no significant change in the ventral third. The lesion did not produce a change in either the affinity or maximum binding capacity of the alpha 1-adrenoceptors in any of the three regions of the hippocampus, as assessed by the binding of the radioligand [125I]BE 2254. This result indicates that reported increases in the response to noradrenaline in hippocampal slices after denervation is most likely due to a loss of noradrenaline uptake mechanisms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
311-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6097843-Afferent Pathways,
pubmed-meshheading:6097843-Animals,
pubmed-meshheading:6097843-Female,
pubmed-meshheading:6097843-Hippocampus,
pubmed-meshheading:6097843-Kinetics,
pubmed-meshheading:6097843-Norepinephrine,
pubmed-meshheading:6097843-Phenethylamines,
pubmed-meshheading:6097843-Radioligand Assay,
pubmed-meshheading:6097843-Rats,
pubmed-meshheading:6097843-Rats, Inbred Strains,
pubmed-meshheading:6097843-Receptors, Adrenergic, alpha,
pubmed-meshheading:6097843-Tetralones
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pubmed:year |
1984
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pubmed:articleTitle |
Deafferentation of the rat hippocampus does not alter the affinity or binding capacity for the alpha 1-adrenoceptor radioligand [125I]BE 2254.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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