Linked Life Data

6097763

Source:http://linkedlifedata.com/resource/pubmed/id/6097763

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-3-11
pubmed:abstractText
Oronasal inoculation of minimal-disease cats with a virulent field isolate of canine coronavirus elicited a neutralizing antibody response that increased steadily over a two-month period, indicating in vivo amplification of the inoculated dose. A heterologous neutralizing antibody response to transmissible gastroenteritis virus could be detected three weeks after titers to canine coronavirus were first observed and was found to parallel the homologous response at a level approximately one log10 dilution lower. A modest anamnestic response detectable in both assays was observed after a second exposure to canine coronavirus. Cross-reacting antibodies to transmissible gastroenteritis virus were not detected by a kinetics-based enzyme-linked immunosorbent assay (KELA), however, until after cats had received multiple daily doses of canine coronavirus (third exposure). No clinical signs attributable to canine coronavirus were seen in inoculated cats, and virus could not be isolated from fecal or rectal swabs nor identified in fecal specimens by electron microscopy. Both virus-neutralizing and KELA titers were boosted by aerosol challenge with feline infectious peritonitis virus. Antibodies produced in response to canine coronavirus did not sensitize cats to subsequent feline infectious peritonitis virus challenge, but neither did they protect cats against the challenge dose.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0023-6764
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
592-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Experimental inoculation of cats with canine coronavirus and subsequent challenge with feline infectious peritonitis virus.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't