Linked Life Data

6097460

Source:http://linkedlifedata.com/resource/pubmed/id/6097460

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-3-5
pubmed:abstractText
The failure of alpha 1-adrenoceptor antagonists, prazosin and indoramin, to cause a reflex tachycardia was investigated in the anaesthetised cat. Recordings were made of preganglionic sympathetic nerve activity from the third or fourth white ramus communicans, femoral arterial conductance, heart rate and blood pressure. A 1 h infusion of prazosin or indoramin caused falls in preganglionic sympathetic nerve activity, heart rate and blood pressure. Infusion of phentolamine differed, in that there was an increase in preganglionic sympathetic nerve activity and heart rate along with a fall in blood pressure. Indoramin differed from prazosin and phentolamine in that it only caused a small increase in femoral arterial conductance. It is suggested that the ability of prazosin and indoramin to cause a reduction in central thoracic sympathetic outflow may explain the failure of these drugs to cause a reflex tachycardia in man and experimental animals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
507-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
The effect of prazosin, indoramin and phentolamine on sympathetic nerve activity.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't