Linked Life Data

6096745

Source:http://linkedlifedata.com/resource/pubmed/id/6096745

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1985-2-5
pubmed:abstractText
Recently, the concept of behavioral teratology has evolved. In animal models, prenatal exposure to low doses of psychotropics (e.g., methadone, diazepam) results in abnormal development of behavior. Furthermore, in animals, pre- and perinatal exposure to psychoactive drugs results in altered brain neurochemistry. In humans, similar behavioral and neurological disruptions have been reported. The mechanisms responsible for these effects are unknown; however, all of these psychotropics have high affinity, specific interactions with various neurotransmitter receptors. Furthermore, normal development of nervous tissue appears to be mediated through neurotransmitter receptors. Disruption of normal, receptor-mediated "signals" by psychoactive agents would be expected to alter development of brain. In order to examine the regulation of neurotransmitter receptors by centrally acting agents, we have compared placental neurotransmitter receptors from "control" and substance-abusing women, hypothesizing that (1) placental neurotransmitter receptor regulation may mirror fetal brain neurotransmitter receptor regulation and (2) placental neurotransmitter receptors themselves may play a role in development. Standard radioligand binding methods were employed. Control values were relatively consistent while substance-abusing values were inconsistent, with wide variation in each substance-abusing group, possibly indicative of "regulation" of neurotransmitter receptors, yet certainly complicated by other variables surrounding gestation and birth (e.g., drug dosage and schedule, length of labor). In this regard, levels of neurotransmitter receptors were consistently higher (20-100%) in caesarian section tissue, possibly reflecting "down-regulation" of neurotransmitter receptors in placentas by the known excess sympathetic and opiate activity during labor.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0275-1380
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-301
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Prenatal exposure to drugs of abuse in humans: effects on placental neurotransmitter receptors.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't