Linked Life Data

6095856

Source:http://linkedlifedata.com/resource/pubmed/id/6095856

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
1984-12-27
pubmed:abstractText
The possible involvement of cerebral cAMP-phosphodiesterase (PDE) in the intoxication and brain edema formation after exposure to triethyltin (TET) has been studied in vitro and in vivo in the rat. In vitro studies showed an irreversible inhibition of the particulate and soluble phosphodiesterase activities. In vivo, both high i.v. single dose and repeated oral administration of low TET doses led to a significant decrease of the particulate activities. Phosphodiesterase inhibition preceded edema formation. The soluble activities were less influenced and their inhibition could be a consequence of the edema formed in the brain tissue rather than of a TET direct action upon the enzyme. Kinetic analysis of the brain particulate enzyme from the TET-treated rats showed a significant decrease in the Vmax of the substrate high affinity enzyme form when compared to controls.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-2952
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3603-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Decreased adenosine cyclic 3',5'-monophosphate phosphodiesterase activity in rat brain following triethyltin intoxication.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't